Which of the following is NOT a commonly tested seizure trigger?

• A. Sleep deprivation
• B. Fever
• C. Hyperglycemia
• D. Alcohol withdrawal

Answer: (C)

Seizure triggers that exam questions commonly focus on are factors that acutely lower the brain’s seizure threshold. Sleep deprivation does this by disturbing normal brain rhythms and increasing cortical excitability, so seizures are more likely when someone hasn’t slept well. Fever raises metabolic demands and temperature, which can provoke seizures, especially in children with febrile seizures. Alcohol withdrawal also heightens neuronal excitability as inhibitory control wanes, making seizures more probable during withdrawal.

Hyperglycemia, while it can be involved in various neurological disturbances in metabolic crises, is not a typical trigger highlighted in standard seizure-trigger lists. Hypoglycemia is the more classic metabolic trigger for seizures due to inadequate glucose supply to the brain. Therefore, hyperglycemia is the answer for the option that is NOT a commonly tested seizure trigger.