Which statement best explains why liver function monitoring is necessary with divalproex?

• A. Divalproex is hepatotoxic, so liver function tests are monitored.
• B. Divalproex improves liver function and requires no monitoring.
• C. Liver tests are unnecessary if there are no symptoms.
• D. Monitoring focuses on kidney function, not liver.

Answer: (A)

Valproate (divalproex) carries a real risk of liver injury, so checking liver function tests is a safety measure to catch hepatotoxicity early. Because liver damage can develop quietly, baseline liver enzymes and other labs are obtained before starting therapy and then monitored regularly, especially during the early months or with dose changes. The goal is to detect rising enzymes or other signs of liver trouble promptly so treatment can be adjusted or stopped if needed, preventing more serious harm. This is not about improving liver function, and monitoring liver health is still important even if no symptoms are present. It also isn’t about kidney function, which is a separate consideration.